ABSTRACT
A Clinical study was made of 88 pediatric patients with miliary tuberculosis, who were admitted to the Pediatric Department of Kwangju Christian Hospital during the period of January, 1971 through December, 1980. 1) The incidence of miliary tuberculosis in children was 0.6%(88 cases) of the total pediatric admission cases(13969), and 12.5% (88 cases) of the total pediatric tuberculous patiens(705). 2) The highest incidence was found in those under the age of 3 years, comprising 63.7%(56 cases) of all cases. The sex ratio of male to female was 1.5:1, which is not significant. 3) The most prevalent season was Spring, with 34.1% (30 cases). 4) The source of infection was found within their family in 36.3% (32cases). 5) Only 14.8% (13 cases) had received BCG innoculation. 6) Predisposing factors were found in 24.9% (21 cases) and these were measles, chicken pox, pertussis, typhoid fever in decreasing order of frequency. 7) Chief complaints on admission in the order of frequency were:fever (72.7%), coughing (68.2%), general weakeness (37.5%), vomiting (35.2%). 8) Principal clinical features on admission were marked adnormal auscltatory findings (68.2%), emaciation (54.5%), adnormal neurologic sings (42.0%), cervical lymphaderopathy (39.8%) and hepatosplenmegaly (22.7%). 9) Tuberculin skin test was done in 55 cases and positive reaction was obtained in 21.8% (12 cases). 10) Hematologic findings revealed a mild degree of anemia in 52.3% of all patients and leukocytosis in 75.0%. 11) AFB smear was positive in only 19.3% (17 cases/88), and the highest positive rate was found in sputum (40.0%). 12) Tuberculous meningitis was the most most common disease associated with miliary tuberculosis. 40.9% (36 cases( of all miliary tuberculosis cases were complicated by tuberculous meningitis, with the highest incidence of 72.2% (56 cases) under the age of 3 years. 13) The usual treatment was the triple regimen of INH, PAS and SM, though PAS was replaced by EMB or Rifampin in recent cases, Corticosteroids were added in complicated cases. 14) In 21.6% (19 cases) of total cases, the clinical symptoms and the miliary density on X-ray disappeared after 3 months of treatment. 15) The mortality rate was 10.2% (9 cases/88).
Subject(s)
Child , Female , Humans , Male , Adrenal Cortex Hormones , Anemia , Causality , Chickenpox , Cough , Emaciation , Incidence , Leukocytosis , Measles , Mortality , Mycobacterium bovis , Rifampin , Seasons , Sex Ratio , Skin Tests , Sputum , Tuberculin , Tuberculosis, Meningeal , Tuberculosis, Miliary , Typhoid Fever , Vomiting , Whooping CoughABSTRACT
Serial platelet counts performed at four day intervals on forty two healthy premature infants whose birth weights were less than 2200 grams. The forty two infants were divided into two groups: twelve premature infants weighing less than 1700 grams, and thirty prematures infants weighing over 1700 grams at birth. We evaluated the length of time for the platetet counts of the premature infants to equal that of the full-term infants. Platelet counts also were determined on ninety-nine healthy full-term infants during twenty one days of age. The platelet counts were repeated twice a day. The counts of the twenty-four healthy premature infants and the twenty-two healthy full term infants were compared using the Brecher-Cronkite method. 1) There was no significant differnce in platelet counts between twenty four healthy premature infants and twenty two healthy full-term infants obtained at birth and four hour of life by the method of Brecher-Cronkite and the error of platelet Counts was within 2.4 percent. 2) There was no significant difference in the mean platelet values between premature infants weighing less than 1700 grams(21200/mm3) and weighing over 1700 grams (21900/mm3)during first day of life. It was noted the mean platelet values of forty two premature infants were significantly lower than that of sixty eight full term infants which was 27500/mm3. 3) At nine days of life, the mean platelet values of the forty two premature infants equaled that of the sixty eight full term infants at leveles of 27500/mm3. The platelet values were increase continuously and reached peak level of 370000/mm3at the age of three weeks. Increase of platelet values in premature infants weighing less than 1700 grams at birth was delayed about one week compared with that of the infants over 1700 grams at birth.